Background. The current system of prevention of complications in odontogenic phlegmons is carried out by intensifying anti-inflammatory and detoxification therapy, with the inclusion of hyaluronidase inhibitors - heparin, proteolytic enzymes, improvement of methods of local treatment of purulent in the treatment complex. Material and methods. The study was conducted on 457 patients with phlegmon of odontogenic origin. Studies of blood biochemical parameters of the LBP protein, antibodies, and antigens to the core region of bacteria and their endotoxins were carried out. This study is based on the method of ion exchange chromatography. Results. It was revealed that odontogenic phlegmon occurs against the background of a persistent decrease in the body's immune resistance, which ensures a long and severe course of the disease. At the same time, the use of glycosaminoglycans in odontogenic phlegmons increases the level of immunoglobulins. The complex treatment of odontogenic phlegmon creates optimal conditions for improving blood counts and immune response and reduces the risk of spreading purulent infection in patients with odontogenic phlegmon. Conclusion. The microflora of the surgical wound in odontogenic phlegmons is associated with bacteria of the residual flora constantly present in the oral cavity. The relationship between the level of IgG bacteria associated with the core region and the LBP protein in the blood, exudation, and epithelialization of the surgical wound, reflecting the dynamics of the inflammatory process and compensatory restructuring of the body due to bacterial infection, has been established.