• Published
    18-01-2024
  • Issue
    Vol: 28 Issue: 01, 2024
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CLINICO-MICROBIOLOGICALSTUDYOFCMVINPREGNANTFEMALES WITH BAD OBSTETRIC HISTORY (BOH)

  • 1*Neha Singh, 2Anant DattatrayUrhekar,3Sareena Rao

Keywords:-CMV, mononucleosis syndrome, BOH

ABSTRACT:-
Backgroud: CMV is a virus of paradoxes &can be a potential killer or a silent companion lifelong. It is probably one of the most common infections known to humans & is characterized by self -limiting infection in healthy individual. In addition to inducing severe birth defects, CMV causes a wide spectrum of disorders in older children & adults, ranging from an asymptomatic sub-clinical infection to a mononucleosis syndrome in healthy individuals to disseminated disease in immunocompromised patients. The aim of the study is to assess the seroprevalence of IgG and IgM antibodies for CMV in women with normal pregnancy, pregnant women with one abortions, age, parity and trimester of pregnancy. Materials and Methods: Serum samples were collected from pregnant women attending antenatal clinic with demographic data. Patients were divided into three groups- Normal pregnant women without any history of abortion (N), pregnant patients with one abortion (A1) and those with two or more abortions (A2) that is those with a Bad Obstetric History (BOH). 71 serum samples were subjected for determination of CMV IgM antibodies and 63 for CMV IgG antibodies. The study was carried out over a period of two years from November 2012 to October 2014. Results: Research findings indicated that CMV IgM prevalence was 12.67% and that of IgG was 92.06%. The distribution showed increase of IgG and IgM antibodies with increase in the number of abortions. In normal group patient’s (N) IgG was mostly positive for patients with gestational age 3rd trimester (29-40weeks). The distribution also showed that in this group IgG was most positive for those in the age group 20-25 years. In group A1 patient’s IgG was found to be equally positive for those with gestational age 2nd trimester (13-28 weeks) and 3rd trimester (29-40 weeks).. In this group IgG was mostly positive for those in the age group 20- 25 years. The distribution for group A2 patient’s showed an increase of IgG antibodies for those with gestational age 3rd trimester (29-40 weeks). The patients of this group also showed increased IgG in the age group 20-25 years. Conclusion: High prevalence of IgG indicates largely sub-clinical infection. The overall IgM prevalence was 12.67% which indicated recent exposure of the patients. In normal group patients, only 1 was found to be positive for IgM antibodies. She belonged to age group 36-40 years and gestational age 1st trimester (1-12 weeks). In group A1 patients IgM was found to be equally positive for those with gestational age 2nd trimester (13-28weeks) and 3rd trimester (29-40weeks) .In this group IgG was mostly positive for those in the age group 20-25 years. The distribution for group A2 patients showed an increase of IgM for those with gestational age 3rd trimester (29-40 weeks) and age group 20-25 years.