• Published
  • Issue
    Vol: 28 Issue: 01, 2024


  • Vikraman K S, S. Rajeshkumar, T. Lakshmi, Dr Anitha Roy

Keywords: Piper longum, Stevia, antioxidant, anticariogenic

AIM: To study the anticariogenic and antioxidant activity of piper longum and stevia formulation. INTRODUCTION: Pharmacological activities of plants and plant derived drugs necessitates for the search of new and useful drugs globally. Long pepper (Piper longum), sometimes called Indian long pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used a spice and a seasoning. Piper longum has various pharmacological activities such as stomachic, aphrodisiac, thermogenic, carminative, expectorant, digestive, emollient, anti-giardiasis, anti-amoebic and antiseptic activity, and used to treat respiratory tract infection, chronic gut related pain, gonorrhoea, menstrual pain, tuberculosis, and arthritic conditions. Stevia is a natural non-caloric sweetener, with more sweetness than sucrose, without adverse effects. Stevia improves the antioxidative defence in adipose tissue and vascular wall and prevents the development of atherosclerotic plaque MATERIAL AND METHODS: Piper longum and Stevia were dried and made into a powder. 2.5g of Piper longum and Stevia were collected and dissolved in 100ml distilled water. And were boiled for 30-40 min at 50 degrees Celsius. The solution was filtered by using Whatman no. 1 filter paper and evaluated for anticariogenic and antioxidant activity. RESULTS AND DISCUSSION: The different concentration of Piper longum and Stevia formulation showed dose dependent antimicrobial activity and antioxidant activity against the tested microorganisms that includes Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis and Candida albicans. CONCLUSION: The present study showed that piper longum and stevia formulation has proven to be a better choice against oral bacteria Streptococcus mutans and Enterococcus faecalis. Hence, this extract may be utilized for the control of such infection.